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Why I Got Tested For The Alzheimer's Gene In My 30s

One writer took a test to determine their risk for Alzheimer's disease. Here's what he learned.

By Dan Koday, Prevention
I never really considered my brain health until I was in my early 30s. I had always been pretty sharp when it came to memory, and most people in my life—friends, family, and colleagues—were always impressed by how I could recall remarkably specific details of certain stories.But around that lovely age when your metabolism slows down and your first gray hairs start to appear—aka your early 30s—something changed with my memory. 

[post_ads]I started having a harder time recalling the names of places I had very distinctly been. I noticed that I was struggling at work to keep my to-do list straight and forgetting to add things to it. I couldn't remember to follow up on things I had meant to be following up on. Most worrisome of all, I noticed a weird little habit any time I was in the kitchen: I started to put things back in the wrong places. Hummus, which normally belongs in the fridge, would somehow end up in a cabinet; meanwhile, a roll of paper towels would end up in the fridge.

Sure, everyone's brains seem to short circuit from time to time, especially when the pressures of a 50-plus hour work week is your reality. But the more it happened, the more I started to get worried. I mentioned the onset of these symptoms to a friend who introduced me to Tammy Motola, co-founder of Rezilir Health, a primary care clinical group in Hollywood, Florida.

I told Tammy how I was worried about the fact that my brain health was a little, well, off, and that I was considering seeing a neurologist or other doctor to find out what was going on. I even mentioned (and I recognize how flippant this could sound, but I truly was concerned) that I might be showing signs of early-onset Alzheimer's.

Upon hearing all this, she reassured me that I could have a test done that would give me an early clue as to whether or not I was at a greater risk for the disease. While Alzheimer's doesn't run in my family (being related to someone who suffers from Alzheimer's makes you more likely to develop the disease, according to the Alzheimer's Association), I was instantly intrigued.

The test she was referring to would look for the APOE-4 gene, which is "present in approximately 20% of people, increases the risk for Alzheimer's, and lowers the age of onset," says Penny Dacks, Ph.D., the former director of aging and Alzheimer's disease prevention at the Alzheimer's Drug Discovery Foundation.

The reason why this is important for women in particular: Tania Dempsey, M.D., who specializes in treating chronic diseases, including Alzheimer's, says women who carry the APOE-4 gene are at an even greater risk than their male counterparts. "Women seem to be more affected by this gene, and it is believed to be through its interaction with estrogen," she says.
In my case, getting the test—which costs about $150—to see if I had the APOE-4 gene was pretty simple. I met Motola's partner, Craig P. Tanio, M.D., co-founder of Rezilir Health, where we discussed the test and a nurse took my blood work. My blood sample was sent to a lab, where Tanio says the blood is examined to see if I have the gene. The test went out on a Thursday, and my results were in the following Tuesday.

The test came back negative for APOE-4. Still, that doesn't mean I definitively won't get Alzheimer's.
"It is important to note that while having the APOE-4 gene increases the risk of Alzheimer's, it is not a guarantee for getting the disease," says Dempsey. Likewise, not having the gene doesn't mean you won't get Alzheimer's. "There are many possible imbalances that are involved in the development of Alzheimer's," she adds.

Little is known about Alzheimer's, but what we do know is that proteins called beta-amyloid and tao build up in the brain, tangling around its cells and essentially killing each cell. Those with it can lose fine motor skills, memory, and the ability to speak, drive, write, or even recognize their own family.

There is good news, though. Had my test come back positive, Tanio says he would have recommended following a treatment program to manage my health and the potential development of Alzheimer's.

"There is good randomized clinical trial data—a recent example is the FINGER study—suggesting that aggressive lifestyle changes can positively affect disease progression in Alzheimer's," Tanio says.

[post_ads]The FINGER study found that people with early cognitive decline could change their diet (e.g., limiting sugar, avoiding saturated fats, eating fish twice a week); engage in more social interaction (through group and individual therapy); control their blood pressure (evidence links brain and heart health); and exercise (through strength training and cardio) and see better cognitive function than people who didn't make the changes. 

The best part about these types of preventative measures, Dempsey says, are that they may help improve outcomes with other chronic diseases, too, including diabetes, heart disease, and cancer.

Even though I didn't have the APOE-4 gene and there's no guarantee I won't develop Alzheimer's later in life, going through the process helped to educate me on some of the preventative measures I can be taking right now—in good health—to reduce the chances that I'll ever show symptoms.

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Health & Fitness: Why I Got Tested For The Alzheimer's Gene In My 30s
Why I Got Tested For The Alzheimer's Gene In My 30s
One writer took a test to determine their risk for Alzheimer's disease. Here's what he learned.
Health & Fitness
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